An Exploratory Study Of 68Ga-DOTA-SEMA In Preoperative Precise Imaging Of Patients With Glucagon-Like Peptide-1 Receptor (GLP1R) Positive Insulinomas

Study Overview

An Exploratory Study of 68Ga-DOTA-SEMA in Preoperative Precise Imaging of Patients with Glucagon-Like Peptide-1 Receptor (GLP1R) Positive Insulinomas

Traditional imaging techniques for insulinomas have a low detection rate. This study aims to evaluate the safety, internal radiation dosimetry, and targeted imaging capability of the novel GLP1R imaging agent, 68Ga-DOTA-SEMA, in patients with GLP1R-positive insulinomas.

N/A

Hypoglycaemia

RADIATION: 68Ga-DOTA-SEMA

AHSWMU-2024-072

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates	Results Reporting Dates	Study Record Updates
First Submitted 2024-12-28	Results First Submitted N/A	Last Update Submitted that met QC Criteria 2025-03-12
First Submitted that Met QC Criteria 2024-12-28	Results First Submitted that Met QC Criteria N/A	Last Update Posted (ACTUAL) 2025-03-25
First Posted (ACTUAL) 2025-03-25	Results First Posted N/A	Last Verified 2024-12

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

Primary Purpose:
Diagnostic

Allocation:
Na

Interventional Model:
Single Group

Masking:
None

Arms and Interventions

Participant Group/Arm	Intervention/Treatment
EXPERIMENTAL: Experimental group	RADIATION: 68Ga-DOTA-SEMA 68Ga-DOTA-SEMA is GLP1R imaging agent

Participant Group/Arm

Intervention/Treatment

EXPERIMENTAL: Experimental group

RADIATION: 68Ga-DOTA-SEMA

68Ga-DOTA-SEMA is GLP1R imaging agent

Primary Outcome Measures	Measure Description	Time Frame
Radiation dose to major organs and tumors		7 days

Secondary Outcome Measures	Measure Description	Time Frame

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.

Ages Eligible for Study:
ALL

Sexes Eligible for Study:
18 Years

Accepts Healthy Volunteers:

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Publications

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

No publications available

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Resources

Patients

Caregivers

Clinical Trial Record