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Molecular Subtyping for Prognosis Evaluation in Resected Pancreatic Adenocarcinoma


2018-03-14


2020-08-03


2021-09-13


226

Study Overview

Molecular Subtyping for Prognosis Evaluation in Resected Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma (PAAD) patients following surgeries are prone to relapse shortly, while it is not well understood by current biomarkers. Given the potential associations of human leukocyte antigen class I (HLA-I) genotype with oncogenic mutational profile and immunotherapy efficacy, we aimed to assess whether differential HLA-I genotype could predict the postoperative outcomes in resected PAAD patients.

N/A

  • Pancreatic Cancer Resectable
  • DEVICE: Multigene panel for next-generation sequencing
  • M-Cli200633-PC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates Results Reporting Dates Study Record Updates

2022-07-29  

N/A  

2022-07-31  

2022-07-31  

N/A  

2022-08-02  

2022-08-02  

N/A  

2022-07  

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

Primary Purpose:
N/A


Allocation:
N/A


Interventional Model:
N/A


Masking:
N/A


Arms and Interventions

Participant Group/ArmIntervention/Treatment
Primary Outcome MeasuresMeasure DescriptionTime Frame
Disease-free survival (DFS)Comparison of DFS between patients with specific HLA-I genotypes or not2 years
Secondary Outcome MeasuresMeasure DescriptionTime Frame

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.

Ages Eligible for Study:
ALL

Sexes Eligible for Study:
34 Years

Accepts Healthy Volunteers:

    Inclusion Criteria:

  • Radically resected pancreatic adenocarcinoma (stage I-III)
  • Resected tumor tissues and matched blood cells available
  • Signed informed consent

  • Exclusion Criteria:

  • Pancreatic cancer except pancreatic adenocarcinoma
  • Non-radical resection

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

  • GeneCast Biotechnology Co., Ltd.

  • : ,

Publications

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

No publications available